Joel Barish, heartbroken that his girlfriend underwent a procedure to erase him from her memory, decides to do the same. However, as he watches his memories of her fade away, he realises that he still loves her, and may be too late to correct his mistake.
Kenneth Bianchi is a security guard whose attempts to become a police officer are repeatedly thwarted. He moves to California to live with his cousin Angelo and dates a string of women, becoming increasingly preoccupied with sex. Eventually the cousins decide to start an escort agency. After violently killing a prostitute they thought had betrayed them, Kenneth and Angelo begin committing a series of crimes that become a media sensation.